Therapeutic agent delivery systems and devices

A device for controlled release of one or more active ingredients, the device comprising:

• a) at least two release apertures, each release aperture operably associated with a deflectable member comprising a rupturable membrane and/or a deflectable cap;
• b) a base comprising a porous membrane layer, and a non-porous substrate layer in contact with the porous membrane layer;
• and
• c) at least two chambers, each chamber juxtaposed between a respective one of the release apertures and the porous membrane layer, each chamber containing a matrix comprising one or more active ingredients and an agent that expands when contacted with an aqueous solution,
• wherein the non-porous substrate layer comprises a plurality of channels configured with at least two pre-determined patterns, each pre-determined pattern adapted for fluid communication with a respective one of the chambers, and wherein each channel of the plurality of channels is suitable for contacting the porous membrane layer with an aqueous solution,
• wherein the device is suitable for implantation in a biological system.