Pre-filled active vial having integral plunger assembly

A pre-filled pod assembly comprising:

• a pre-filled pod having a distal end, a proximal end, and a sidewall extending therebetween defining an interior;
• a transitionable stopper disposed within the interior of the pre-filled pod;
• and
• a regulator coupled to the proximal end of the pre-filled pod and provided in fluid communication with the interior of the pre-filled pod comprising:
• an inlet, an outlet, and a housing defining a cavity between the inlet and the outlet:
• a valve that controls flow through the inlet and into the cavity;
• and
• an outlet valve that controls flow out of the cavity and through the outlet;
• wherein when the valve and the outlet valve are both in a closed position, the cavity is sealed, and when the valve is in an open condition, pressurized gas or fluid may enter the cavity, and when the outlet valve is in an open position, pressurized gas or fluid stored in the cavity may pass through the outlet, and wherein the outlet of the regulator is in fluid communication with the interior of the pod such that pressurized gas or fluid flowing from the outlet of the regulator enters the interior of the pod advancing the transitionable stopper from an initial position to an activated position in which at least a portion of a fluid contained within the interior of the pre-filled pod is advanced therefrom.