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US 8,617,083 B2Granted
Method and apparatus for predicting work of breathing
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsNeil R. Euliano, Victor L. Brennan, Paul B. Blanch, Michael J. Banner
Life of this patent
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Abstract
A method of creating a non-invasive predictor of both physiologic and imposed patient effort from airway pressure and flow sensors attached to the patient using an adaptive mathematical model. The patient effort is commonly measured via work of breathing, power of breathing, or pressure-time product of esophageal pressure and is important for properly adjusting ventilatory support for spontaneously breathing patients. The method of calculating this non-invasive predictor is based on linear or nonlinear calculations using multiple parameters derived from the above-mentioned sensors.
Claims20
A method for estimating actual effort of breathing of a patient, comprising:
- receiving respiratory parameters of the patient;
- calculating respiratory data from the respiratory parameters;
- inputting the respiratory data into a mathematical model created using clinical data from a population of patients, wherein the clinical data includes pleural pressure or a surrogate of pleural pressure;
- and
- generating, using the mathematical model, at least one output variable corresponding to quantified patient respiratory effort,
- wherein the quantified patient respiratory effort is an estimate of the patient's actual effort of breathing throughout an entire breath, and
- wherein the at least one output variable is generated by a processor configured to run the mathematical model.
4 more elements
A method for estimating actual effort of breathing of a patient, comprising:
- receiving respiratory parameters of a patient, wherein the respiratory parameters comprise one or more of airway pressure, airway flow, airway volume, carbon dioxide flow, and pulse oximeter plethysmogram;
- calculating respiratory data from the respiratory parameters, wherein the respiratory data comprises one or more of tidal volume, breathing frequency, peak inspiratory pressure, inspiratory time, occlusion pressure at 0.1 seconds after breath initiation trigger time, trigger depth, respiratory resistance, respiratory compliance, end-tidal carbon dioxide, variations in the pulse oximeter plethysmogram, and concavity/convexity of a pressure waveform;
- inputting the respiratory data into a mathematical model configured from clinical data collected from a population of patients to predict effort of breathing, wherein the clinical data includes pleural pressure or a surrogate of pleural pressure;
- and
- generating, using the mathematical model, at least one output variable corresponding to quantified patient respiratory effort,
- wherein the quantified patient respiratory effort is an estimate of the patient's actual effort of breathing throughout an entire breath and
- wherein the at least one output variable is generated by a processor configured to run the mathematical model.
4 more elements
An apparatus for estimating actual effort of breathing of a patient, comprising:
- a processing device for calculating respiratory data from respiratory parameters of the patient, wherein the respiratory parameters comprise one or more of airway pressure, airway flow, airway volume, carbon dioxide flow, and pulse oximeter plethysmogram, and wherein the respiratory data comprises one or more of tidal volume, breathing frequency, peak inspiratory pressure, inspiratory time, occlusion pressure at 0.1 seconds after breath initiation trigger time, trigger depth, respiratory resistance, respiratory compliance, end-tidal carbon dioxide, variations in the pulse oximeter plethysmogram, and concavity/convexity of a pressure waveform;
- a mathematical modeling device created using clinical data collected from a population of patients to receive the respiratory data and predict the actual effort of breathing, wherein the clinical data includes pleural pressure or a surrogate of pleural pressure;
- and
- an output signal that provides at least one output variable from the mathematical model corresponding to quantified patient respiratory effort,
- wherein the quantified patient respiratory effort is an estimate of the patient's actual effort of breathing throughout an entire breath.
2 more elements
A system for estimating actual effort of breathing of a patient, comprising:
- means for measuring respiratory parameters of the patient, wherein the respiratory parameters comprise one or more of airway pressure, airway flow, airway volume, carbon dioxide flow, and pulse oximeter plethysmogram;
- means for calculating respiratory data from the respiratory parameters, wherein the respiratory data comprises one or more of tidal volume, breathing frequency, peak inspiratory pressure, inspiratory time, occlusion pressure at 0.1 seconds after breath initiation trigger time, trigger depth, respiratory resistance, respiratory compliance, end-tidal carbon dioxide, variations in the pulse oximeter plethysmogram, and concavity/convexity of a pressure waveform;
- means for predicting effort of breathing using a mathematical model created using clinical data collected from a population of patients that receives the respiratory data, wherein the clinical data includes pleural pressure or a surrogate of pleural pressure;
- and
- means for providing at least one output variable generated from the mathematical model corresponding to quantified patient respiratory effort,
- wherein the quantified patient respiratory effort is an estimate of the patient's actual effort of breathing throughout an entire breath.
3 more elements
Dependencies are inferred from the claim text.