US 8,614,318 B2Granted

Apoptosis promoters

AssigneeAbbVie Inc.

InventorsMilan Bruncko, Hong Ding, Steven Elmore, Aaron Kunzer, Christopher L. Lynch, William McClellan, Cheol-Min Park, Andrew Petros, Xiaohong Song, Xilu Wang, Noah Tu, Michael Wendt, Alexander R. Shoemaker, Michael J. Mitten

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Abstract

Disclosed are compounds which inhibit the activity of anti-apoptotic protein family members, compositions containing the compounds and uses of the compounds for preparing medicaments for treating diseases during which occurs expression one or more than one of an anti-apoptotic protein family member.

Claims2

Dependent claims

A compound selected from the group consisting of:

N-(6-(4-((4′-chloro(1,1′-biphenyl)-2-yl)methyl)piperazin-1-yl)-1,2-benzisoxazol-3-yl)-3-nitro-4-((2-(phenylsulfanyl)ethyl)amino)benzenesulfonamide;
N-(6-(4-((4′-chloro(1,1-biphenyl)-2-yl)methyl)piperazin-1-yl)-1,2-benzisoxazol-3-yl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrobenzenesulfonamide;
N-(6-(4,4-dimethylpiperidin-1-yl)-1,2-benzisoxazol-3-yl)-3-nitro-4-((2-(phenylsulfanyl)ethyl)amino)benzenesulfonamide;
N-(6-(4,4-dimethylpiperidin-1-yl)-1,2-benzisoxazol-3-yl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrobenzenesulfonamide;
N-(6-(4-(3,3-diphenylpropen-2-yl)piperazin-1-yl)-1,2-benzisoxazol-3-yl)-4-(((1R)-3-(morpholin-4-yl)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrobenzenesulfonamide;
N-(6-(4-(3,3-diphenylpropen-2-yl)piperazin-1-yl)-1,2-benzisoxazol-3-yl)-3-nitro-4-((2-(phenylsulfanyl)ethyl)amino)benzenesulfonamide;
N-(6-(4-((4′-chloro(1,1′-biphenyl)-2-yl)methyl)piperazin-1-yl)-1,2-benzisoxazol-3-yl)-4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-3-nitrobenzenesulfonamide;
and
4-(((1R)-3-(dimethylamino)-1-((phenylsulfanyl)methyl)propyl)amino)-N-(6-(4,4-dimethylpiperidin-1-yl)-1,2-benzisoxazol-3-yl)-3-nitrobenzenesulfonamide, or a therapeutically acceptable salt thereof.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application: 11/491,851Filed 24 Jul 2006 · continuation in part
Priority: 13 Nov 2003
Published: US 2007/0015787 A118 Jan 2007
Granted: 24 Dec 2013
Term ends: Not estimatedThe source records don’t support an estimate.

Classification75 codes

C07D 233/06
Having one double bond between ring members or between a ring member and a non-ring member: with only hydrogen atoms or radicals containing only…
C07D 205/04
Not condensed with other rings: having no double bonds between ring members or between ring members and non-ring members
C07D 207/06
Having no double bonds between ring members or between ring members and non-ring members: with radicals, containing only hydrogen and carbon…
C07D 207/08
Having no double bonds between ring members or between ring members and non-ring members: with hydrocarbon radicals, substituted by hetero atoms,…

Family

Application60/519,695Us provisional application · filed 13 Nov 2003
Application10/988,338Parent of this continuation-in-part · filed 12 Nov 2004
Application11/127,940Parent of this continuation-in-part · filed 12 May 2005
Application11/202,827Parent of this continuation-in-part · filed 12 Aug 2005
US 2007/0015787 A1Pre-grant publication · published 18 Jan 2007
US 7,642,260 B2Parent of this continuation-in-part
US 7,767,684 B2Parent of this continuation-in-part
US 2005/0159427 A1Published application
US 2006/0128706 A1Published application
US 2006/0258657 A1Published application
US 8,614,318 B2This patent

From the US filing history. Foreign family members aren’t listed.