Concentrated aqueous silk fibroin solution and use thereof
AssigneeTrustees of Tufts College
InventorsDavid L. Kaplan, Ung-Jin Kim, Jaehyung Park, Hyoung-Joon Jin
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Abstract
The present invention provides for concentrated aqueous silk fibroin solutions and an all-aqueous mode for preparation of concentrated aqueous fibroin solutions that avoids the use of organic solvents, direct additives, or harsh chemicals. The invention further provides for the use of these solutions in production of materials, e.g., fibers, films, foams, meshes, scaffolds and hydrogels.
Claims20
A fiber produced by the method comprising processing a concentrated aqueous fibroin solution comprising a fibroin concentration of at least 10 wt % in order to form a fiber, wherein the fibroin solution is free of organic solvents and wherein the fibroin solution is produced by a process comprising dialyzing an aqueous silk fibroin solution against a hygroscopic polymer for a sufficient time to result in an aqueous fibroin solution of at least 10 wt %, wherein the hygroscopic polymer has a molecular weight of at least 8,000 g/mol.
Dependencies are inferred from the claim text.