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US 8,613,621 B2Granted
Simulated tissue, body lumens and body wall and methods of making same
AssigneeColorado State University Research Foundation
InventorsDean A. Hendrickson, Fausto Bellezzo
Life of this patent
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Abstract
An artificial body wall is disclosed herein. The artificial body wall may include a first layer and a second layer. The first layer is substantially formed of a silicone rubber and includes at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer. The second layer extends along and below the first layer and is substantially formed of a silicone rubber. The second layer includes at least one of an artificial fascia layer or an artificial muscle layer. At least one of the first layer or second layer may be vascularized.
Claims32
An artificial body wall comprising:
- a first layer substantially formed of a silicone rubber and including both an artificial epidermis-dermis layer and an artificial subcutaneous layer, the artificial subcutaneous layer extending along and below the artificial epidermis-dermis layer;
- and
- a second layer extending along and below the first layer and substantially formed of a silicone rubber, wherein the second layer includes at least one of an artificial fascia layer or an artificial muscle layer,
- wherein the silicone rubber of the artificial epidermis-dermis layer includes a mixed combination including a platinum cured room temperature vulcanization silicone rubber (“PCRTVS”) having a Shore durometer of A10 and a PCRTVS having a Shore durometer of OO50.
1 more element
An artificial body wall comprising:
- a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- and
- a second layer extending along and below the first layer and substantially formed of a silicone rubber, wherein the second layer includes both an artificial fascia layer and an artificial muscle layer, the artificial muscle layer at least one of extending along and below the artificial fascia layer or extending between first and second layers of the artificial fascia layer,
- wherein the silicone rubber of the artificial fascia layer includes a mixed combination including a PCRTVS having a Shore durometer of A10 and a PCRTVS having a Shore durometer of A20.
1 more element
An artificial body wall comprising:
- a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- a second layer extending along and below the first layer and substantially formed of a silicone rubber, wherein the second layer includes both an artificial fascia layer and an artificial muscle layer, the artificial muscle layer at least one of extending along and below the artificial fascia layer or extending between first and second layers of the artificial fascia layer;
- and
- a third layer including at least one of an artificial peritoneum layer, an artificial pleura layer or an artificial sub-peritoneal fat layer, the third layer extending along and below the second layer and substantially formed of a silicone rubber,
- wherein the silicone rubber of the third layer includes a mixed combination including at least one of a PCRTVS having a Shore durometer of A10, a PCRTVS having a Shore durometer of A20, a PCRTVS having a Shore durometer of OO50, or a thixotropic agent.
2 more elements
An artificial body wall comprising:
- a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- a second layer extending along and below the first layer and substantially formed of a silicone rubber, wherein the second layer includes both an artificial fascia layer and an artificial muscle layer, the artificial muscle layer at least one of extending along and below the artificial fascia layer or extending between first and second layers of the artificial fascia layer;
- and
- an artificial linea alba layer extending along and below the second layer and substantially formed of a silicone rubber,
- wherein the silicone rubber of the artificial linea alba layer includes a mixed combination including a PCRTVS having a Shore durometer of A10 and a PCRTVS having a Shore durometer of A20.
2 more elements
An artificial body wall comprising:
- a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- and
- a second layer extending along and below the first layer and substantially formed of a silicone rubber, wherein the second layer includes at least one of an artificial fascia layer or an artificial muscle layer,
- wherein the at least one of the first layer or second layer is vascularized with a plurality of lumens.
1 more element
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including both an artificial epidermis-dermis layer and an artificial subcutaneous layer, the artificial subcutaneous layer being caused to extend along the artificial epidermis-dermis layer after the artificial epidermis-dermis layer has substantially cured;
- and
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including at least one of an artificial fascia layer or an artificial muscle layer,
- wherein the silicone rubber of the artificial epidermis-dermis layer includes a mixed combination including a PCRTVS having a Shore durometer of A10 and a PCRTVS having a Shore durometer of OO50.
1 more element
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including both an artificial epidermis-dermis layer and an artificial subcutaneous layer, the artificial subcutaneous layer being caused to extend along the artificial epidermis-dermis layer after the artificial epidermis-dermis layer has substantially cured;
- and
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including at least one of an artificial fascia layer or an artificial muscle layer,
- wherein the silicone rubber of the artificial subcutaneous layer includes a mixed combination including a first component having PCRTVS having a Shore durometer of A10 and a second component having a PCRTVS having a Shore durometer of between approximately OO10 and approximately OO50.
1 more element
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- and
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including both an artificial fascia layer and an artificial muscle layer, the artificial muscle layer being caused to extend along the artificial fascia layer after the artificial fascia layer has substantially cured,
- wherein the silicone rubber of the artificial fascia layer includes a mixed combination including a PCRTVS having a Shore durometer of A10 and a PCRTVS having a Shore durometer of A20.
1 more element
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- and
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including both an artificial fascia layer and an artificial muscle layer, the artificial muscle layer being caused to extend along the artificial fascia layer after the artificial fascia layer has substantially cured,
- wherein the silicone rubber of the artificial muscle layer includes a mixed combination including a PCRTVS having a Shore durometer of OO10 and a PCRTVS having a Shore durometer of OO30.
1 more element
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including at least one of an artificial fascia layer or an artificial muscle layer;
- and
- causing a third layer to extend along the second layer after the second layer has substantially cured, the third layer including at least one of an artificial peritoneum layer, an artificial pleura layer or an artificial sub-peritoneal fat layer, the third layer being substantially formed of a silicone rubber,
- wherein the silicone rubber of the third layer includes a mixed combination including at least one of a PCRTVS having a Shore durometer of A10, a PCRTVS having a Shore durometer of A20, a PCRTVS having a Shore durometer of OO50, or a thixotropic agent.
2 more elements
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including at least one of an artificial fascia layer or an artificial muscle layer;
- and
- causing an artificial linea alba layer to extend along the second layer after the second layer has substantially cured, the artificial linea alba layer being substantially formed of a silicone rubber,
- wherein the silicone rubber of the artificial linea alba layer includes a mixed combination including a PCRTVS having a Shore durometer of A10 and a PCRTVS having a Shore durometer of A20.
2 more elements
A method of manufacturing an artificial body wall, the method comprising:
- molding a first layer substantially formed of a silicone rubber and including at least one of an artificial epidermis-dermis layer or an artificial subcutaneous layer;
- after the first layer has substantially cured, causing a second layer to extend along the first layer, the second layer substantially formed of a silicone rubber and including at least one of an artificial fascia layer or an artificial muscle layer;
- and
- causing at least one of the first layer or second layer to be vascularized with a plurality of lumens.
1 more element
Dependencies are inferred from the claim text.