Enzyme inhibiting compounds and methods
AssigneeThe Board of Trustees of the University of Illinois
InventorsEric Oldfield, Ke Wang, Weixue Wang, Yonghui Zhang
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Abstract
The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria. The compounds and compositions can also be used as antibiotics, for example, to kill bacteria or parasites, or to inhibit bacterial or parasite growth. The invention further provides inhibitors of isoprenoid biosynthesis enzymes, and methods of inhibiting the activity of isoprenoid biosynthesis enzymes. The compounds can be, for example, alkynes or allenes that bind to a unique Fe of an Fe4S4 cluster of an isoprenoid biosynthesis enzyme.
Claims26
A compound of Formula III:
- wherein
- R1 is H;
- CF3;
- N(Rx)2 where each Rx is independently H, (C1-C4)alkyl;
- (C1-C4)alkanoyl;
- or (C1-C4)alkyl substituted by hydroxy, halo, amino, or nitro;
- or R1 is absent when X is N;
- X is C or N;
- n is 0, 1, or 2;
- L1 is O, S, NR2, or C(R3)(R4);
- L2 is O, S, NR2, or C(R3)(R4);
- each R2 is independently H or (C1-C4)alkyl;
- each R3 is independently H, halo, or (C1-C4)alkyl;
- and
- each R4 is independently H, halo, or (C1-C4)alkyl;
- or a salt or solvate thereof.
Dependencies are inferred from the claim text.