Method and apparatus for forming delivery devices for oral intake of an agent
AssigneeIntec Pharma Ltd.
InventorsMoshe Tsabari, Avner Balshey, Erez Yofe, Michael Friedman
Life of this patent
Estimating the term…
Abstract
Provided are methods, systems and apparatuses for producing delivery devices, for example, for oral intake of an agent. The method can include assembling one or more layers including one or more materials with an agent or an agent-releasing formulation to form an intergraded device; folding the intergrated delivery device to form a folded integrated delivery device; and at least partially enclosing the folded delivery device to a form suitable for oral delivery.
Claims20
A gastro-retentive agent delivery device for oral intake, the device configured for unfolding from a folded configuration for oral intake to an unfolded configuration for gastric retention, the device comprising:
- two external layers sandwiching a functional layer therebetween;
- the functional layer comprising at least one layer comprising an agent or agent-releasing formulation;
- the functional layer being configured for imparting mechanical strength to the device sufficient to enable, upon unfolding of the device, the preservation of said unfolded configuration to provide gastric retention;
- at least one said external layer comprising perforations,
- wherein in the folded configuration the device has a plurality of folds and a device axis, said folds being of increasingly smaller amplitudes upon extending away from the device axis so as to form a partially rounded cross section.
Dependencies are inferred from the claim text.