Method for the treatment of metabolic disorders
AssigneeWellstat Therapeutics Corporation
InventorsShalini Sharma, Reid W. Von Borstel, Kirvin L. Hodge, Michael K. Bamat, Stephen D. Wolpe
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Abstract
Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Claims7
A method for treating a mammalian subject with a condition selected from the group consisting of insulin resistance syndrome and Type II Diabetes, comprising administering to the subject an amount of a biologically active agent effective to treat the condition, wherein the agent is a compound of the formula:
- wherein
- n is 0, 1 or 2;
- R1 is hydrogen or alkyl having from 1 to 3 carbon atoms;
- R15 is hydrogen or alkyl having from 1 to 3 carbon atoms;
- R9 is hydrogen, halo, hydroxy, or alkoxy having from 1 to 3 carbon atoms;
- A is phenyl, unsubstituted or substituted by 1 or 2 groups selected from halo, alkyl having 1 or 2 carbon atoms, perfluoromethyl, alkoxy having 1 or 2 carbon atoms, and perfluoromethoxy;
- or
- cycloalkyl having from 3 to 6 ring carbon atoms wherein the cycloalkyl is unsubstituted or one or two ring carbons are independently mono-substituted by methyl or ethyl;
- or
- a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms selected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of formula CXVII by a ring carbon;
- or a pharmaceutically acceptable salt of the compound.
Dependencies are inferred from the claim text.