Back to results
US 8,603,487 B2Granted
Palmitoylated AB 1-15 in a liposome as a treatment for amyloid associated diseases
AssigneeAC Immune SA
InventorsAndrea Pfeifer, Claude Nicolau
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeAC Immune SA
InventorsAndrea Pfeifer, Claude Nicolau
Estimating the term…
The present invention is related to methods and compositions for the therapeutic and diagnostic use in the treatment of diseases and disorders which are caused by or associated with amyloid or amyloid-like proteins including amyloidosis. In particular, the present invention provides novel methods and compositions for eliciting a highly specific and highly effective immune response in an organism, but particularly within an animal, particularly a mammal or a human, which is capable of preventing or alleviating amyloidosis, or the symptoms associated with amyloidosis, a group of diseases and disorders associated with amyloid plaque formation including secondary amyloidosis and age-related amyloidosis including, but not limited to, neurological disorders such as Alzheimer's Disease (AD), including diseases or conditions characterized by a loss of cognitive memory capacity such as, for example, mild cognitive impairment (MCI).
A method for the treatment of an amyloid-associated disease or condition comprising administering to an animal suffering from such a disease or condition an immunogenic composition comprising one or more copies of a palmitoylated Aβ1-15 peptide antigen reconstituted in a liposome, wherein the Aβ1-15 peptide antigen is (a) pre-formed by on-resin standard automated peptide synthesis and (b) then modified by on-resin grafting of a palmitoyl moiety to the terminal amino acid residues of the pre-formed Aβ peptide and administration of the immunogenic composition results in a T-cell independent immune response.
A method for significantly increasing the retention or cognitive memory capacity of a mammal, in need thereof comprising administering to the mammal an immunogenic composition comprising a palmitoylated Aβ1-15 peptide antigen reconstituted in a liposome wherein the Aβ1-15 peptide antigen is (a) pre-formed by on-resin standard automated peptide synthesis and (b) then modified by on-resin grafting of a palmitoyl moiety to the terminal amino acid residues of the pre-formed Aβ peptide and administration of the immunogenic composition results in a T-cell independent immune response.
A method for inducing an immune response in an animal, suffering from an amyloid-associated condition characterized by a loss of cognitive memory capacity comprising administering to the animal a therapeutic immunogenic composition comprising a palmitoylated Aβ1-15 peptide antigen reconstituted in a liposome, wherein the Aβ1-15 peptide antigen is (a) pre-formed by on-resin standard automated peptide synthesis and (b) then modified by on-resin grafting of a palmitoyl moiety to the terminal amino acid residues of the pre-formed Aβ peptide and administration of the immunogenic composition results in a T-cell independent immune response such that the retention or cognitive memory capacity of the treated animal is increased as compared to the retention of cognitive memory capacity prior to administration.
Dependencies are inferred from the claim text.