Devices and methods for filling a flexible liquid medicament container with liquid from a liquid medicament reservoir

A method for filling a flexible liquid medicament container with a liquid from a liquid medicament reservoir, the method for filling the flexible liquid medicament container comprising:

• evacuating a flexible container;
• pressurizing a liquid reservoir;
• transferring a liquid from the liquid reservoir to the flexible container with a pressure difference between the liquid reservoir and the flexible container;
• decreasing an inner volume of a pressurizing chamber, containing a pressurizing gas, fluidly connected directly to the liquid reservoir thereby transferring increased pressure to the liquid reservoir and allowing the gas to contact the liquid within the liquid reservoir;
• and
• increasing an inner volume of an evacuation chamber fluidly connected directly to the flexible container.

A device for filling a flexible liquid medicament container with a liquid from a liquid medicament reservoir, the device for filling a liquid medicament container comprising:

• a pressurizing chamber;
• an evacuation chamber;
• a first displacement piston sealingly and slideably arranged within the pressurizing chamber, wherein the first displacement piston defines a first inner volume within the pressurizing chamber;
• a second displacement piston sealingly and slideably arranged within the evacuation chamber, wherein the second displacement piston defines a second inner volume within the evacuation chamber;
• a pressurizing conduit fluidly connected to the first inner volume of the pressurizing chamber;
• a reservoir adapter fluidly connected directly to the pressurizing conduit and which connects to a liquid reservoir;
• wherein the reservoir adapter comprises a first hollow needle and a second hollow needle, both which penetrate a septum of the liquid reservoir;
• the first hollow needle is fluidly connected to the pressurizing conduit;
• and
• the second hollow needle is fluidly connected to the evacuation conduit;
• an evacuation conduit fluidly connected directly to the second inner volume of the evacuation chamber;
• a container adapter fluidly connected directly to the evacuation conduit and which connects with a flexible container;
• a transfer conduit fluidly connected directly to the reservoir adapter and the container adapter;
• and
• a valve that fluidly connects the container adapter to either the evacuation conduit or the transfer conduit.