Back to results
US 8,598,205 B2Granted
Modulators of cystic fibrosis transmembrane conductance regulator
AssigneeVertex Pharmaceuticals Incorporated
InventorsHayley Binch, Lev T. D. Fanning, Dennis Hurley, Urvi Sheth, Alina Silina, Xiaoqing Yang, Martyn Botfield, Peter D. J. Grootenhuis, Fredrick Van Goor, Mehdi Michel Djamel Numa
Life of this patent
Estimating the term…
Abstract
The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
Claims22
A compound of Formula (I):
- or pharmaceutically acceptable salts thereof, wherein:
- ring A is selected from:
- wherein:
- R1 is —CF3, —CN, or —C≡CCH2N(CH3)2;
- R2 is hydrogen, —CH3, —CF3, —OH, or —CH2OH;
- R3 is hydrogen, —CH3, —OCH3, or —CN;
- provided that both R2 and R3 are not simultaneously hydrogen.
4 more elements
A compound selected from
Dependencies are inferred from the claim text.