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US 8,592,178 B2Granted
Process for the preparation of testosterone
AssigneeF.I.S. Fabbrica Italiana Sintetici S.p.A.
InventorsStefano Fogal, Elisabetta Bergantino, Riccardo Motterle, Andrea Castellin, Giancarlo Arvotti
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Abstract
The present invention relates to an industrial process for the reduction of 4-androstene-3,17-dione in order to obtain testosterone using a particularly stable and selective enzyme produced in a recombinant manner.
Claims13
An industrial process for the synthesis of testosterone comprising the biocatalytic reduction of 4-androstene-3,17-dione using the recombinant murine enzyme Type V 17β-hydroxysteroid dehydrogenase, wherein said recombinant murine enzyme Type V 17β-hydroxysteroid dehydrogenase has the amino acid sequence of SEQ. ID NO:
- 2.
Dependencies are inferred from the claim text.