Combination therapies employing GITR binding molecules

A method for treating a subject having a tumor, the method comprising administering a GITR-binding antibody, or an antigen-binding fragment thereof, and a therapy, to the subject,

• wherein the GITR-binding antibody or the antigen-binding fragment acts as a GITR agonist, and the therapy is administered at a separate time from the GITR-binding antibody or the antigen-binding fragment at least once, and
• wherein the therapy is cytotoxic or exerts an anti-proliferative effect on cells.