Compositions and methods for enhancing metal ion dependent drug therapies
AssigneeCNSS IP Holdings, Inc.
InventorCharles N. S. Soparkar
Life of this patent
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Abstract
Methods and compositions are provided for increasing responsiveness to therapeutic metalloproteases including increasing and/or maximizing responsiveness and preventing botulinum and tetanus toxin resistance due to a functional deficiency of zinc. Also provided are methods for zinc replacement or supplement in lacking individuals comprising the administration of a zinc supplement for a loading period and/or administration of a phytase supplement together with the zinc supplement. Also provided are methods for standardization of botulinum toxin potency assays that provide for greater certainty and margins of safety in the use of products from different manufacturers.
Claims24
A method of preparing a subject for therapeutic metalloprotease administration, comprising:
- providing a sufficient quantity of zinc and a phytase that insures availability of a zinc ion required for activity of a therapeutic metalloprotease,
- administering the zinc and the phytase for a loading period prior to, concurrent with, or shortly following administration of the therapeutic metalloprotease,
- wherein the administration of the zinc and the phytase results in an availability of the required zinc ion at a sufficient level to eliminate a functional deficiency of the zinc ion as a cause for poor or limited responsiveness to the administered therapeutic metalloprotease.
A method of preparing a subject for therapeutic metalloprotease administration, comprising:
- providing a sufficient quantity of at least one supplement, including a phytase supplement, that insures availability of a metal ion required for activity of a therapeutic metalloprotease,
- administering the at least one supplement for a loading period prior to, concurrent with, or shortly following administration of the therapeutic metalloprotease,
- wherein the administration of the at least one supplement results in an availability of the required metal ion at a sufficient level to eliminate a functional deficiency of the metal ion as a cause for poor or limited responsiveness to the administered therapeutic metalloprotease.
Dependencies are inferred from the claim text.