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US 8,586,357 B2Granted
Markers of definitive endoderm
AssigneeViaCyte, Inc.
InventorsKevin Allen D'Amour, Alan D Agulnick, Emmanuel Edward Baetge
Life of this patent
Estimating the term…
Abstract
Disclosed herein are reagent-cell complexes comprising one or more definitive endoderm cells. Also described herein are compositions for detecting definitive endoderm. Method of enriching, isolating and/or purifying definitive endoderm cells are also disclosed.
Claims9
An isolated human cell population wherein at least 20% of cells in said cell population form an ex vivo reagent-cell complex comprising:
- a human definitive endoderm cell expressing a marker selected from the group consisting of CALCR, CMKOR1, CXCR4, GPR37, NTN4, RTN4RL1, SLC5A9, SLC40A1, and TRPA1, said definitive endoderm cell being a multipotent cell that can differentiate into cells of the gut tube or organs derived therefrom;
- and
- a reagent bound to said marker.
An isolated human cell population wherein at least 20% of cells in said cell population form an ex vivo reagent-cell complex comprising:
- a human definitive endoderm cell expressing CXCR4, said definitive endoderm cell being a multipotent cell that can differentiate into cells of the gut tube or organs derived therefrom and a reagent bound to CXCR4.
Dependencies are inferred from the claim text.