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US 8,586,306 B2Granted
Preservation of cell-free RNA in blood samples
AssigneeStreck, Inc.
InventorM. Rohan Fernando
Life of this patent
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Abstract
A method for preserving and processing cell-free nucleic acids located within a blood sample is disclosed, wherein a blood sample containing cell-free nucleic acids is treated to reduce both blood cell lysis and nuclease activity within the blood sample. The treatment of the sample aids in increasing the amount of cell-free nucleic acids that can be identified and tested while maintaining the structure and integrity of the nucleic acids.
Claims15
A composition comprising:
- a. one or more nuclease inhibitors including aurintricarboxylic acid;
- b. one or more preservative agents including diazolidinyl urea;
- and
- c. two or more metabolic inhibitors including glyceraldehyde and sodium fluoride;
- and
- d. EDTA.
3 more elements
A composition comprising:
- a. from about 0.5% to about 2.5% by weight of aurintricarboxylic acid;
- b. from about 20% to about 30% by weight diazolidinyl urea;
- c. from about 0.05% to about 1.5% by Weight sodium fluoride:
- d. from about 1% to about 8% by weight glyceraldehyde;
- and
- e. from about 5% to about 15% by weight EDTA.
3 more elements
Dependencies are inferred from the claim text.