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US 8,586,044 B2Granted
Treatment of chronic pelvic pain syndrome
AssigneeNorthwestern University
InventorsPraveen Thumbikat, Anthony J. Schaeffer, Joseph Done, David J. Klumpp, Charles Rudick
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Abstract
The present invention provides compositions and methods for detection, diagnosis, treatment and/or prevention of chronic pelvic pain syndrome. In particular, the present invention provides biomarkers of chronic pelvic pain syndrome (e.g., mast cell markers (e.g., tryptase)), and/or inhibition of mast cell function (e.g. inhibition of MCP-1 and/or MIP-1α) to treat or prevent chronic pelvic pain syndrome.
Claims9
A method for treating chronic pelvic pain syndrome in a subject, comprising administering to said subject a therapeutically effective amount of:
- (a) a mast cell stabilizer;
- (b) a combination of:
- (i) a mast cell stabilizer and
- (ii) a histamine receptor 1 antagonist and/or a histamine receptor 2 antagonist;
- or
- (3) a combination of:
- (i) a mast cell stabilizer,
- (ii) a histamine receptor 1 antagonist and/or a histamine receptor 2 antagonist, and
- (iii) an inhibitor of MCP-1 or MIP-1α, wherein the inhibitor is an antibody which binds MCP-1 or MIP-1α.
6 more elements
Dependencies are inferred from the claim text.