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US 8,586,029 B2Granted
Prevention or treatment of immune-relevant disease by modification of microfloral populations
AssigneeTrustees of Dartmouth College
InventorsLloyd H. Kasper, Javier Ochoa-Repáraz
Life of this patent
Estimating the term…
Abstract
The present invention is a method for preventing or treating an immune-relevant disease by modulating commensal microbiota populations via antibiotics, exogenous microbiota and/or probiotics.
Claims3
A method for treating an autoimmune disease comprising administering to a first subject an antibiotic;
- administering to the first subject exogenous Bacteroides;
- isolating a CD25+CD4+ T cell population comprising at least 75% FoxP3+ CD25+CD4+ regulatory T cells from the first subject colonized with the exogenous Bacteroides;
- and administering said T cell population to a second subject having an autoimmune disease so that the autoimmune disease is treated.
Dependencies are inferred from the claim text.