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US 8,586,006 B2Granted
Organ-specific proteins and methods of their use
AssigneesInstitute for Systems Biology, Integrated Diagnostics, Inc.
InventorsLeroy Hood, Patricia M. Beckmann, Richard Johnson, Marcello Marelli, Xiaojun Li
Life of this patent
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Abstract
The present invention relates generally to methods for identifying and using organ-specific proteins and transcripts. The present invention further provides compositions comprising organ-specific proteins and transcripts encoding the same, detection reagents for detecting such proteins and transcripts, and diagnostic panels, kits and arrays for measuring organ-specific proteins/transcripts in blood, biological tissue or other biological fluid.
Claims6
A method for detecting an abnormal prostate state in a subject comprising,
- a) contacting a blood sample from the subject with a panel of at least four detection reagents wherein each detection reagent is specific for one prostate-specific protein;
- wherein the prostate-specific proteins are selected from the prostate-specific protein set as follows;
- SEQ
- Gene
- Protein ID
- ID NO
- Description
- ANXA8*&
- NP_001621
- 384
- annexin A8
- CAV1&
- NP_001744
- 1351
- caveolin 1
- CLCA2*
- NP_006527
- 59346
- calcium activated chloride
- channel 2
- COL17A1*
- NP_000485
- 59347
- alpha 1 type XVII collagen
- H2BFS
- NP_059141
- 65564
- H2B histone family, member S
- HIST1H2BC
- NP_003517
- 65565
- H2B histone family, member L
- HIST1H2BD&
- NP_066407
- 14604
- H2B histone family, member B
- HIST1H2BE
- NP_003514
- 65566
- H2B histone family, member H
- HIST1H2BJ
- NP_066402
- 65567
- H2B histone family, member R
- HIST1H2BM
- NP_003512
- 65568
- H2B histone family, member E
- HIST1H2BN
- NP_003511
- 65569
- H2B histone family, member D
- HIST1H2BO
- NP_003518
- 65570
- histone H2B
- HNT*&
- NP_057606
- 4329
- neurotrimin
- IL1A*
- NP_000566
- 59357
- interleukin 1, alpha proprotein
- KRT6A*&
- NP_005545
- 6225
- keratin 6A
- KRT6B*&
- NP_005546
- 17263
- keratin 6B
- KRT6C*&
- NP_490596
- 6226
- keratin 6C
- LAMA3*
- NP_000218
- 59362
- laminin alpha 3 subunit
- isoform 2
- LAMA3*
- NP_937762
- 59363
- laminin alpha 3 subunit
- isoform 1
- LAMB3*
- NP_000219
- 59364
- laminin subunit beta 3 precursor
- LAMB3*
- NP_001017402
- 59365
- laminin subunit beta 3 precursor
- LOC653107*
- XP_931601
- 65577
- PREDICTED:
- similar to
- Annexin A8 (Annexin VIII)
- (Vascular anticoagulant-beta)
- (VAC-beta) isoform 1
- LOC653107*
- XP_936422
- 65578
- PREDICTED:
- similar to
- Annexin A8 (Annexin VIII)
- (Vascular anticoagulant-beta)
- (VAC-beta) isoform 2
- LOC653107*
- XP_936471
- 65585
- PREDICTED:
- similar to
- Annexin A8 (Annexin VIII)
- (Vascular anticoagulant-beta)
- (VAC-beta) isoform 10
- LOC653107*
- XP_936481
- 65587
- PREDICTED:
- similar to
- Annexin A8 (Annexin VIII)
- (Vascular anticoagulant-beta)
- (VAC-beta) isoform 12
- LOC653107*
- XP_936484
- 65588
- PREDICTED:
- similar to
- Annexin A8 (Annexin VIII)
- (Vascular anticoagulant-beta)
- (VAC-beta) isoform 13
- LOC653107*
- XP_936492
- 65589
- PREDICTED:
- similar to
- Annexin A8 (Annexin VIII)
- (Vascular anticoagulant-beta)
- (VAC-beta) isoform 14
- MASP1*&
- NP_624302
- 14670
- mannan-binding lectin serine
- protease 1 isoform 2 precursor
- S100A2&
- NP_005969
- 30938
- S100 calcium binding
- protein A2
- SCRN3*
- NP_078859
- 65605
- secernin 3
- SEMA3C*
- NP_006370
- 65606
- semaphorin 3C
- SEPT11*&
- NP_060713
- 4577
- septin 11
- SERPINB5*
- NP_002630
- 59403
- serine (or cysteine) proteinase
- inhibitor, clade B (ovalbumin),
- member 5
- SFN*
- NP_006133
- 59405
- stratifin
- b) measuring the amount of prostate-specific protein detected in the blood sample by each detection reagent;
- and
- c) comparing the amount of prostate-specific protein detected in the blood sample by each detection reagent to a predetermined normal control amount for each respective prostate-specific protein;
- wherein a statistically significant altered level in said prostate-specific proteins indicates a perturbation in the normal biological state.
175 more elements
Dependencies are inferred from the claim text.