Components for producing amphoteric liposomes

A compound comprising the structure shown in Formula (I):

• amphoteric substance—Y—spacer—amphiphilic substance (Formula (1)), wherein:
• (a) the amphoteric substance comprises a cationic portion having a pKa of from 4 to 8, and an anionic portion with a pKa of from 3 to 7, wherein
• aa) the cationic portion is a substituted or unsubstituted morpholine or piperazine ring;
• and
• bb) the anionic portion is a carboxyl group;
• (b) Y is selected from the group consisting of —(C═O)—O—;
• —(C═O)—NH—;
• —NH—(C═O)—O—;
• —O—;
• —NH—;
• —CH═N—;
• —O—(O═C)—;
• —S—;
• —(O═C)—;
• —NH—(O═C)—;
• —O—(O═C)—NH— and —N═CH—;
• (c) the spacer is from 1 to 8 carbon atoms;
• and
• (d) the amphiphilic substance is selected from the group consisting of an acid group, amine containing group;
• a structure shown in Formula (II) and a structure shown in Formula (III), wherein
• aa) the acid group is esterified with linear C8-C30 alcohols, and selected from the group consisting of a dicarboxylic acid;
• aspartic acid;
• glutamic acid;
• malic acid;
• tartaric acid;
• citric acid;
• aconitic acid;
• citraconic acid and maleic acid;
• bb) the amine group is amidated with linear C8-C30 fatty acids, and selected from the group consisting 1,4-diamine;
• 1,5-diamine of 3-aminoalanine;
• diaminobutyric acid;
• ornithine and lysine;
• cc) Formula (II) is
• and;
• dd) Formula (III) is
• wherein X is selected from the group consisting of —O—(C═O);
• —NH—(C═O)—;
• —S—(C═O)—;
• —O—;
• —NH—;
• —S—;
• —N═CH—;
• —(O═C)—O—;
• —S—(O═C)—;
• —NH—(O═C)— and —N═CH—;
• and R1 and R2 are, independently, a C8-C30 alkyl chain or a C8-C30 acyl chain.