Adjuvant compositions
AssigneeZoetis LLC
InventorsPaul J. Dominowski, Ramasamy M. Mannan, Richard L. Krebs, James R. Thompson, Tedd A. Childers, Mary K. Olsen, Robert J. Yancey, Jr., Risini Weeratna, Shucheng Zhang, Cedo M. Bagi
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Abstract
This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.
Claims32
A vaccine composition comprising an adjuvant formulation and a therapeutically effective amount of an antigen component, wherein the adjuvant formulation comprises a saponin, a sterol, a quaternary ammonium compound, a polymer, and an ORN/ODN,
- wherein the saponin is Quil A or a purified faction thereof, the sterol is cholesterol, the quaternary ammonium compound is dimethyl dioctadecyl ammonium bromide (DDA), the polymer is polyacrylic acid, and the ORN/ODN is a CpG.
An avian coccidiosis vaccine, for in ovo administration, which comprises:
- (a) an adjuvant that comprises Quil A or a purified fraction thereof including QS21, cholesterol, CARBOPOL, DDA, and R1005;
- and
- (b) a protozoan antigen selected from (1) one or more recombinantly expressed proteins, (2) one or more proteins or other macromolecules isolated from said protozoan by conventional means, and (3) whole cell extracts or preparations from said protozoan.
Dependencies are inferred from the claim text.