Immunomodulating compositions and methods of use
AssigneesWhitehead Institute, Massachusetts Institute of Technology, Trustees of Boston University, The General Hospital Corporation
InventorsIfat Rubin-Bejerano, Gerald R. Fink, Claudia Abeijon, Danial S. Kohane, Jason E. Fuller, Robert S. Langer
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Abstract
This invention is directed to β-1-6-glucans, compositions and devices comprising the same, and methods of use thereof in modulating immune responses. The β-1-6-glucans of certain embodiments of the invention are enriched for O-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
Claims45
A composition comprising β-1-6-glucan linked to a targeting moiety that targets a neoplastic cell, a pre-neoplastic cell or a component thereof wherein said targeting moiety is an antibody or antigen-binding fragment thereof.
A composition comprising β-1-6-glucan linked to an antibody or antigen-binding fragment thereof.
A composition comprising β-1-6-glucan linked to a targeting moiety that binds to a tumor antigen wherein said targeting moiety is an antibody or antigen-binding fragment thereof.
Dependencies are inferred from the claim text.