PS-1 antibodies in combination with a cytokine-secreting cell and methods of use thereof

A method of cancer immunotherapy comprising:

• administering a cytokine-expressing cellular immunotherapy comprising cells modified to express GM-CSF and a single chain antibody that specifically binds to human Programmed Death 1 (anti-PD-1) to a subject with cancer,
• wherein the modified cells are rendered proliferation-incompetent by irradiation, and
• wherein administration of the cells modified to express GM-CSF and the single chain antibody results in enhanced therapeutic efficacy relative to administration of an anti-PD-1 antibody alone or cells modified to express GM-CSF alone.