Back to results
US 8,577,620 B2Granted
Methods for assessing drug efficacy and response of patient to therapy
OwnerGus J. Slotmaninventor
Life of this patent
Estimating the term…
Abstract
Methods of identifying, monitoring and matching patients with appropriate treatments who are at risk for developing a systemic inflammatory condition using a systemic mediator-associated physiologic test profile are provided. The methods of the present invention increase the likelihood of demonstrating clinical efficacy in clinical trial datasets.
Claims4
A method for identifying a subject whose host-inflammatory responses to a systemic inflammatory condition are matched to the mechanism of action of a therapeutic agent for the treatment of the subject comprising:
- (a) obtaining one or more baseline parameters of a subject with a systemic inflammatory condition, wherein said baseline parameters comprise one or more demographic variables, physiologic variables, or results of hospital laboratory tests;
- (b) generating, on a computer, from the baseline parameters, a systemic mediator-associated response test (SMART) profile for the subject;
- (c) using statistical tests to compare the SMART profile of the subject with one or more control SMART profiles comprising independent variables for subjects who have responded positively to a therapeutic agent with a predetermined mechanism of action;
- (d) identifying whether the SMART profile of the subject has independent variables of the control SMART profile for the therapeutic agent with a predetermined mechanism of action;
- (e) selecting the therapeutic agent with the predetermined mechanism of action and treating the subject.
2 more elements
Dependencies are inferred from the claim text.