Back to results
US 8,575,375 B2Granted
Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
AssigneesResearch Triangle Institute, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsScott P. Runyon, Michael A. Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
Life of this patent
Estimating the term…
Abstract
This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
Claims1
A compound of structure 4, wherein:
- R1 is H or (optionally substituted) C1-4 alkyl, C3-6 cycloalkyl, C2-4 alkynyl, C2-4 alkenyl, C6-10 aryl, 2-arylsubstituted ethynyl, arylsubstituted C1-4 alkyl, arylsubstituted C2-4-alkenyl, arylsubstituted C3-6 cycloalkyl, heterocycle;
- 2-heterocycle-substituted ethynyl, heterocycle-substituted C1-4 alkyl, heterocycle-substituted C2-4-alkenyl, or heterocycle-substituted C3-6 cycloalkyl;
- R4 is H or Me;
- and stereoisomers and pharmaceutically acceptable compositions salts thereof.
1 more element
Dependencies are inferred from the claim text.