Method for manufacturing neuraminic acid derivatives
AssigneeDaiichi Sankyo Company, Limited
InventorsYoshitaka Nakamura, Masakazu Wakayama, Kazuhiro Umeo
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Abstract
Methods for manufacturing neuraminic acid compounds and synthetic intermediates of neuraminic acid compounds, including a method for manufacturing a compound represented by wherein R2 represents a C1-C4 alkyl, R3 represents a C1-C6 alkyl, R4 and R5 represent a hydrogen atom, a C1-C6 alkyl or a phenyl, or R4 and R5 together form a tetramethylene, a pentamethylene or an oxo, and Ac represents an acetyl, comprising reacting a compound represented by wherein R2 represents a C1-C4 alkyl, R3 represents a C1-C6 alkyl, R4 and R5 represent a hydrogen atom, a C1-C6 alkyl or a phenyl, or R4 and R5 together form a tetramethylene, a pentamethylene or an oxo, with trimethylsilyl azide in the presence of a Lewis acid.
Claims2
A method for manufacturing a compound represented by the following formula (9):
- wherein R2 represents a C1-C4 alkyl group, R3 represents a C1-C6 alkyl group, R4 and R5, independently from each other, represent a hydrogen atom, a C1-C6 alkyl group or a phenyl group, or R4 and R5 together form a tetramethylene group, a pentamethylene group or an oxo group, and Ac represents an acetyl group, comprising:
- reacting a compound represented by the following formula (8):
- wherein R2 represents a C1-C4 alkyl group, R3 represents a C1-C6 alkyl group, R4 and R5, independently from each other, represent a hydrogen atom, a C1-C6 alkyl group or a phenyl group, or R4 and R5 together form a tetramethylene group, a pentamethylene group or an oxo group, with trimethylsilyl azide in the presence of a Lewis acid.
Dependencies are inferred from the claim text.