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US 8,575,362 B2Granted
Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds
AssigneeLexicon Pharmaceuticals, Inc.
InventorsMark S. Bednarz, Hugh Alfred Burgoon, Jr., Shinya Iimura, Ramanaiah C. Kanamarlapudi, Qiuling Song, Wenxue Wu, Jie Yan, Haiming Zhang
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Abstract
Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.
Claims9
A method of preparing a compound of formula II(a):
- which comprises Noyori hydrogenation of a compound of formula IV:
- with a platinum group metal catalyst having a Noyori-type chiral ligand, wherein:
- A1 is pyrazole;
- R1 is chloro;
- and
- m is 1.
3 more elements
Dependencies are inferred from the claim text.