Derivatives of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-carboxylic acid amides

A compound of formula I:

• wherein:
• R1 is selected from —CN, —OCF3, —CF3, halogen, heteroaryl optionally substituted with halogen or C1-3 alkyl and phenyl optionally substituted with halogen;
• R2 is —Cl or —CF3;
• R3 is H or halogen;
• X is a group
• wherein
• R4 is selected from:
• (A)-H;
• (B) C1-3 alkyl optionally substituted with one or two groups selected from:
• a) C3-6cycloalkyl;
• b) —OR9;
• c) —NR9R10;
• d) —SOR9;
• e) —SO2R9;
• f) —C(O)NR9R10;
• g) —C(O)OR9;
• h) heteroaryl, optionally substituted with C1-3 alkyl;
• i) heterocycyl, optionally substituted with C1-3 alkyl;
• and
• j) phenyl optionally substituted with C1-3 alkyl;
• (C) C3-6cycloalkyl;
• (D)heteroaryl;
• and
• (E) phenyl, optionally substituted with halogen, —OR9, —CN or —CF3;
• R5 is H or C1-3alkyl;
• or
• R4 and R5, together with the carbon they are bonded to, form a saturated hydrocarbon ring with 3-7 carbon atoms and wherein one carbon atom in said hydrocarbon ring may be optionally replaced by —O—, —S—, —S(O)—, —SO2—, —NH—, —NCH3—, or —NC(O)CH3—;
• Y is a group
• wherein
• R6 is H or C1-3alkyl;
• R7 is H or C1-3alkyl;
• or
• R6 and R7, together with the carbon they are bonded to, form a saturated hydrocarbon ring with 3-7 carbon atoms wherein one carbon atom in said hydrocarbon ring may be optionally replaced by —O—, —S—, —S(O) —, —SO2—, —NH—, —NCH3—, or —NC(O)CH3—;
• Z is aryl or heteroaryl;
• R8 is selected from:
• (A) aryl optionally substituted with one or two groups selected from:
• (a) C1-3alkyl optionally substituted with —OR9, —NR9R10 or —NR9SO2R10;
• (b) C3-7cycloalkyl optionally substituted with —OR9 or —NR9R10;
• (a) —OR9;
• (c) halogen;
• (d) —C(O)NR9R10;
• (e) —SO2NR9R10;
• (f) —NR9(CO)R10;
• (g) —SO2R9;
• (h) —NR9R10;
• (i) —CN;
• (j) —C(O)OR9;
• (k) —NR9SO2R10;
• and
• (l) —C(O)R9;
• and
• (B) heteroaryl optionally substituted with one to two groups selected from:
• (a) C1-3alkyl optionally substituted with —OR9, NR9R10 or halogen;
• (b) C3-7cycloalkyl optionally substituted with —OR9, NR9R10;
• (a) —OR9;
• (c) halogen;
• (d) —C(O)NR9R10;
• (e) —SO2NR9R10;
• (f) —NR9(CO)R10;
• (g) —SO2R9;
• (h) —NR9R10;
• and
• (i) —CN;
• R9 is selected from H, C1-5alkyl or C3-7cycloalkyl;
• R10 is selected from H, C1-5alkyl or C3-7cycloalkyl;
• or a pharmaceutically acceptable salt thereof.