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US 8,575,347 B2Granted
Muscarinic acetylcholine receptor antagonists
AssigneeGlaxo Group Limited
InventorsDramane Ibrahim Laine, Michael R. Palovich, Brent W. McCleland, Christopher E. Neipp, Sonia M. Thomas
Life of this patent
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Abstract
Muscarinic Acetylcholine Receptor Antagonists and methods of using them are provided.
Claims30
A compound of formula (I)
- wherein:
- R1 is
- R2 and R3 are independently selected from the group consisting of:
- where F, G, H, K, and L are independently selected from the group consisting of hydrogen, halogen, —C1-4 alkyl, halosubstituted —C1-4 alkyl, hydroxyl substituted alkyl, and —C1-4 alkoxy;
- m is an integer having a value of 1 to 15;
- X, Y, Z, and W are independently selected from the group consisting of hydrogen and —C1-4 alkyl;
- X− is a pharmaceutically acceptable anion selected from the group consisting of chloride, bromide, iodide, hydroxide, sulfate, nitrate, phosphate, acetate, trifluoroacetate, fumarate, citrate, tartrate, oxalate, succinate, mandelate, methanesulfonate, and p-toluenesulfonate.
4 more elements
A compound of formula (I)
- wherein:
- R1 is selected from the group consisting of —C1-15 alkyl, halosubstituted —C1-15 alkyl, —C1-15alkyl cycloalkyl, —C2-15 alkenyl, hydroxyl substituted —C1-15 alkyl, —C1-15 alkylaryl, —C1-15 alkyl heteroaryl, —(CR7R7)qNRaRa, —(CR7R7)qNC(O)Ra, —(CR7R7)qNC(O)NRaRa, —(CR7R7)qC(O)Ra, —(CR7R7)qOC(O)Ra, —(CR7R7)qORc, and —(CR7R7)qNS(O)2Ra;
- R2 and R3 are independently selected from the group consisting of:
- wherein F, G, H, K, and L are independently selected from the group consisting of hydrogen, halogen, —C1-4 alkyl, halosubstituted —C1-4 alkyl, hydroxyl substituted alkyl, and —C1-4 alkoxy;
- R7 is selected from a group consisting of hydrogen, —C1-4 alkyl, halosubstituted —C1-4 alkyl, and hydroxysubstituted —C1-4 alkyl;
- Ra is selected from the group consisting of hydrogen, —C1-15 alkyl, —C1-15 alkoxy, aryl, —C1-15 alkyl aryl, heteroaryl, —C1-15 alkyl heteroaryl, heterocyclic, and a —C1-15 alkyl heterocyclic moiety, all of which moieties excluding hydrogen may be optionally substituted;
- Rc is selected from a group consisting of hydrogen, —C1-15 alkyl, —C1-15 alkoxy, heterocyclic, and a —C1-15 alkyl heterocyclic moiety, all of which moieties, excluding hydrogen may be optionally substituted;
- q is 0 or an integer having a value of 1 to 15;
- X− is a pharmaceutically acceptable anion selected from the group consisting of chloride, bromide, iodide, hydroxide, sulfate, nitrate, phosphate, acetate, trifluoroacetate, fumarate, citrate, tartrate, oxalate, succinate, mandelate, methanesulfonate, and p-toluenesulfonate.
6 more elements
Dependencies are inferred from the claim text.