Pyrimidine, pyridine and triazine derivatives as maxi-K channel openers

A compound of formula (A):

• wherein ring A is an aromatic ring or a heteroaromatic ring;
• R1 is independently a halogen, cyano, an alkylthio, a cycloalkyl, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• n is 0, 1, 2, 3 or 4;
• Each of X1, X2 and X3 is independently CR2 or nitrogen, provided that one of X1, X2 and X3 is CR2 and the others are nitrogens;
• R2 is independently hydrogen, a halogen, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one or more substituent(s) independently selected from halogen, an alkoxy and hydroxy;
• Y is carboxy, tetrazolyl or an alkoxycarbonyl;
• D is a group of formula:
• wherein R4 and R5, taken together with the atom(s) to which they are bonded, form a cyclopropane ring optionally substituted by one or more alkyl(s);
• G is —NR10R11, —OR14, a phenyl optionally substituted by one or more R15(s) or a group of formula:
• R10 is an alkyl substituted by one or more substituent(s) independently selected from an alkoxy, hydroxy, and a group of formula:
• or a cycloalkyl optionally substituted by one or more R12(s);
• R11 is hydrogen, or an alkyl optionally substituted by one to three substituent(s) independently selected from an alkoxy and hydroxy;
• R12 is independently a halogen, cyano, an alkylthio, a cycloalkyl, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• R13 is independently hydroxy, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy, a cycloalkyl and hydroxy, an alkylsulfonyl, oxo, a halogen, cyano, an aryl, a heteroary, an aryloxy, a heteroaryloxy, an alkoxycarbnyl or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, hydroxy, and an optionally substituted alkoxy;
• R14 is an alkyl substituted by a group of formula
• or a group of formula
• Ring B1 is a carbocyclic ring, a heterocyclic ring, an aromatic ring or a heteroaromatic ring;
• Ring B2 is a nitrogen containing heterocyclic ring;
• Ring B5 is a carbocyclic ring, a heterocyclic ring, an aromatic ring or a heteroaromatic ring;
• R15 is independently a halogen, cyano, an alkylthio, a cycloalkyl, a cycloalkyloxy, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy, a cycloalkyl and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• R16 is independently a halogen, cyano, an alkylthio, a cycloalkyl, an alkanoyl, an amino optionally substituted by alkyl(s), an alkylsulfonyl, an alkoxy optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy, or an alkyl optionally substituted by one to three substituent(s) independently selected from a halogen, an alkoxy and hydroxy;
• m is 0, 1, 2 or 3;
• and
• r is 0, 1, 2 or 3,
• provided that when G is phenyl optionally substituted by one or more R15, Ring A is an aromatic ring;
• or a pharmaceutically acceptable salt thereof.