Benzylbenzene derivatives and methods of use

A compound having the formula

• wherein
• V is a member selected from the group consisting of oxygen and a single bond;
• W is a member selected from the group consisting of C1-C6 alkylene, C2-C6 alkenylene, and C2-C6 alkynylene, and
• wherein alkylene, alkenylene, and alkynylene groups or portions are optionally partly or completely fluorinated and are optionally mono- or disubstituted by substituents independently selected from the group consisting of chlorine, hydroxy, C1-C3 alkyl, C1-C3 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy, C5-C10 cycloalkenyl and C5-C10 cycloalkenyloxy;
• X is oxygen;
• Y is a member selected from the group consisting of C3-C10 cycloalkyl, C5-C10 cycloalkenyl, (C3-C10 cycloalkyl)C1-C4 alkyl, (C5-C10 cycloalkenyl)C1-C3 alkyl, (C3-C10 cycloalkyl)C1-C4 alkenyl, C3-C6 cycloalkylidenmethyl, (C5-C10 cycloalkenyl)C2-C4 alkenyl, (C3-C10 cycloalkyloxy)C1-C3 alkyl, and (C5-C10 cycloalkenyloxy)C1-C3 alkyl;
• wherein alkyl, alkenyl, cycloalkyl and cycloalkenyl groups or portions are optionally partly or completely fluorinated and are optionally mono- or disubstituted by substituents independently selected from the group consisting of chlorine, hydroxy, C1-C3 alkyl, C1-C3 alkoxy, C3-C6 cycloalkyl, C3-C6 cycloalkyloxy, C5-C10 cycloalkenyl, C5-C10 cycloalkenyloxy, and NRbRc, and in cycloalkyl and cycloalkenyl groups or portions one or two methylene groups are optionally replaced independently of one another by O, S, CO, SO, SO2 or NRb, and one or two methyne groups are optionally replaced by N, wherein the heterocycle formed by said optional replacement is other than heteroaryl, and wherein
• when V is a single bond and W is a member selected from the group consisting of C2-C6 alkenylene, and C2-C6 alkynylene, then Y is other than (C3-C10 cycloalkyl)C1-C4 alkyl;
• and
• when V is oxygen, W is a member selected from the group consisting of C2-C6 alkenylene and C2-C6 alkynylene, and Y is a member selected from the group consisting of C3-C10 cycloalkyl and C5-C10 cycloalkenyl, then X can also represent a single bond;
• R1 is selected from the group consisting of hydrogen, halo, hydroxy, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 cycloalkyl, C5-C10 cycloalkenyl, C1-C6 alkyloxy, C3-C10 cycloalkyloxy, cyano and nitro, wherein alkyl and cycloalkyl groups or portions are optionally mono- or polysubstituted by fluorine
• each Rb is a member independently selected from the group consisting of H, C1-C4 alkyl and (C1-C4 alkyl)carbonyl, wherein alkyl groups or portions are optionally partly or completely fluorinated;
• each Rc is a member independently selected from the group consisting of H, C1-C4 alkyl, C3-C6 cycloalkyl, CHRdRe, SO2Rd, C(O)ORd and C(O)NRdRe, wherein alkyl and cycloalkyl groups are optionally partly or completely fluorinated;
• and
• Rd and Re each independently represent H or C1-C6 alkyl, wherein alkyl groups are optionally partly or completely fluorinated;
• or a pharmaceutically acceptable salt thereof.