Hepatocyte growth factor (HGF) binding proteins
AssigneeAVEO Pharmaceuticals, Inc.
InventorsMay Han, S. Kirk Wright, William M. Winston, Jr., Lyne Breault, Jie Lin, Bijan Etemad-Gilbertson, Christine Knuehl, Jeno Gyuris
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Abstract
The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.
Claims6
An isolated antibody that binds human hepatocyte growth factor (HGF) comprising an immunoglobulin heavy chain variable region comprising the amino acid sequence of SEQ ID NO. 169 and an immunoglobulin light chain variable region comprising the amino acid sequence of SEQ ID NO. 179, or an antigen binding fragment of the antibody.
Dependencies are inferred from the claim text.