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US 8,575,317 B2Granted
Anti-NR10 antibody and use thereof
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTaichi Kuramochi, Keiko Kasutani, Souhei Ohyama, Hiroyuki Tsunoda, Tomoyuki Igawa, Tatsuhiko Tachibana, Hirotake Shiraiwa, Keiko Esaki
Life of this patent
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Abstract
The present inventors successfully obtained anti-NR10 antibodies having an effective neutralizing activity against NR10. The anti-NR10 antibodies provided by the present invention are useful as, for example, pharmaceuticals for treating or preventing inflammatory diseases.
Claims14
An isolated anti-NR10 antibody selected from the group consisting of:
- (1) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 206 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (2) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 207 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (3) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 208 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (4) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 209 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (5) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 210 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (6) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 211 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (7) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 212 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (8) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 213 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (9) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 214 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (10) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 215 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 220;
- (11) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 216 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 221;
- and
- (12) an antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 217 and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 221.
34 more elements
An isolated anti-NR10 antibody selected from the group consisting of:
- (1) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 224 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (2) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 225 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (3) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 226 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (4) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 227 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (5) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 228 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (6) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 229 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (7) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 230 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (8) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 231 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (9) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 232 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (10) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 233 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 238;
- (11) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 234 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 239;
- and
- (12) an antibody comprising a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 235 and a light chain comprising the amino acid sequence of SEQ ID NO:
- 239.
34 more elements
Dependencies are inferred from the claim text.