Collagen peptide conjugates and uses therefor
AssigneePurdue Research Foundation
InventorsJean A Chmielewski, Marcos M Pires, David E Przybyla
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Abstract
Described herein are conjugates of collagen peptides and metal binding agents and compositions resulting therefrom, useful in various tissue engineering and regeneration applications, in cell culture, cell adhesion, cosmetic surgery, construction of artificial skin substitutes, management of severe burns and burn surgery, reconstruction of bone and a wide variety of dental, orthopedic and surgical purposes, as drug delivery vehicles and in delivering populations of cells to a site of disease or injury.
Claims24
A synthetic collagen conjugate capable of forming a type II helix, the conjugate comprising one or more metal-binding moieties, and a peptide comprising a plurality of tripeptides, each of which comprises proline or hydroxyproline, or a combination thereof;
- where the one or more metal-binding moieties are covalently attached to the peptide, optionally with a divalent linker;
- wherein one of said metal-binding moieties is covalently attached to the N-terminus of the peptide, and one of said metal-binding moieties is covalently attached to the C-terminus of the peptide;
- or
- wherein one of said one or more metal-binding moieties is covalently attached to a non-terminal amino acid of the peptide;
- or
- wherein one of said metal-binding moieties is covalently attached to the N-terminus of the peptide, one of said metal-binding moieties is covalently attached to the C-terminus of the peptide, and one of said metal-binding moieties is covalently attached to a non-terminal amino acid of the peptide;
- and
- wherein the conjugate may further comprise a drug or a diagnostic or imaging agent, where the drug or the diagnostic or imaging agent is covalently attached to the peptide, optionally with a divalent linker.
Dependencies are inferred from the claim text.