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US 8,575,309 B2Granted
Delta-opioid receptor selective analgesics
AssigneeBiousian Biosystems, Inc.
InventorsRobin Polt, Edward J. Bilsky
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Abstract
Methods and materials are provided for the production of glycosylated peptides that exhibit high affinity and specificity for delta opioid receptors. The methods and materials of the present invention may be used for treatment of conditions involving pain, such as acute pain and nociceptic pain, neuralgia and myalgia.
Claims11
A glycosylated peptide consisting essentially of an amino acid sequence:
- X1-X2-X3-X4-X5-X6-X7-NH2 (SEQ ID NO:
- 30)
- wherein:
- X1 is Y;
- X2 is dAla;
- X3 is F;
- X4 is E;
- X5 and X6 each are Nle or Nva;
- and
- X7 is selected from Thr, dThr, Ser, or dSer;
- and wherein X7 is glycosylated with beta-D-Glc.
8 more elements
Dependencies are inferred from the claim text.