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US 8,575,306 B2Granted
Target and method for inhibition of bacterial RNA polymerase
AssigneeRutgers, The State University of New Jersey
InventorRichard H. Ebright
Life of this patent
Estimating the term…
Abstract
Target and method for inhibition of bacterial RNA polymerase disclosed are targets and methods for specific binding and inhibition of RNAP from bacterial species.
Claims5
An isolated analog of bacteriocidal-peptide microcin J25 (MccJ25) that (1) has an amino acid sequence that differs from that of MccJ25 in terms of at least one amino acid substitution, insertion, or deletion;
- and (2) that binds a bacterial RNAP and inhibits an activity of bacterial RNAP with a potency at least equal to that of MccJ25 wherein the analog is selected from the group consisting of [Lys5]MccJ25, [Lys13]MccJ25, [Lys15]MccJ25, and [Lys17]MccJ25.
An isolated analog of bacteriocidal-peptide microcin J 25 (MccJ25) that (1) has an amino acid sequence that differs from that of MccJ25 in terms of at least one amino acid substitution, insertion, or deletion;
- and (2) that binds a bacterial RNAP and inhibits an activity of bacterial RNAP with a potency at least equal to that of MccJ 25 wherein the analog is selected from the group consisting of [X-Lys5]MccJ25, [X-Lys13]MccJ25, [X-Lys15]MccJ25, and [X-Lys17]MccJ25, wherein X is a detectable group.
Dependencies are inferred from the claim text.