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US 8,575,305 B2Granted
Cell penetrating peptides
AssigneeMedical Research Council
InventorsMichael John Gait, Andrey Alexandrovich Arzumanov, Gabriela Dimitroval Ivanova
Life of this patent
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Abstract
The present invention discloses cell penetrating peptides and conjugates of a cell penetrating peptide and a cargo molecule.
Claims21
A peptide, having a primary sequence structure comprised of at least three domains, having the arrangement:
- N-terminus [Domain 1]-[Domain 2]-[Domain 3] C-terminus in which:
- (i) Domain 1 comprises a sequence chosen from:
- RXRRBRRXR
- [SEQ ID NO:
- 81]
- RBRRXRRBR,
- [SEQ ID NO:
- 82]
- or
- RXRRXR
- [SEQ ID NO:
- 74]
- (ii) Domain 2 comprises a sequence chosen from:
- ILFQ,
- [SEQ ID NO:
- 86]
- or
- ILIQ
- [SEQ ID NO:
- 202]
- (iii) Domain 3 comprises a sequence chosen from:
- RXRBRXR
- [SEQ ID NO:
- 159]
- RBRXRBR
- [SEQ ID NO:
- 162]
- RXRRXR
- [SEQ ID NO:
- 161]
- RXRXRXR
- [SEQ ID NO:
- 160]
- RXRBRX
- [SEQ ID NO:
- 163]
- MKWHK,
- [SEQ ID NO:
- 203]
- or
- WKWHK
- [SEQ ID NO:
- 204]
- wherein X=aminohexanoyl, B=betaAlanine.
41 more elements
Dependencies are inferred from the claim text.