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US 8,575,304 B2Granted
MEK ligands and polynucleotides encoding MEK ligands
AssigneeIntrexon Corporation
InventorsThomas Reed, Amy Atzel, David Bachinsky, Jonathan Carson
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Abstract
The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate MEK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands, homopolyligands, and heteropolyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Claims25
An isolated polypeptide comprising
- an amino acid sequence at least 80% identical to SEQ ID NO:
- 1 or SEQ ID NO:
- 5 or SEQ ID NO:
- 9 or SEQ ID NO:
- 13 or SEQ ID NO:
- 17 or SEQ ID NO:
- 21 or SEQ ID NO:
- 33,
- wherein said polypeptide inhibits MEK activity.
6 more elements
Dependencies are inferred from the claim text.