US 8,575,282 B2 · Compound modified by a phosphoramidate and/or phosphonamide group and use thereof

Abstract

A modified compound that has at least one further functional group, in particular a bio- or macromolecule, comprising at least one x-fold (x≧1) chemoselectively incorporated phosphoramidate group of general formula (I), NPO(OR1)(OR1′), and/or at least one x-fold (x≧1) chemoselectively incorporated phosphonamide group of general formula (Ia), NPO(R1)(OR1′). R1 and R1′ is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n≧1, Cn-alkyl chains with n≧1; functionalized Cn-alkyl chains with n≧1, aryls, heteroaryl, silyl, lipids, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups. R1 and R1′ can be identical to or different from one another.

Claims12

Dependent claims

A modified macromolecule that has at least one further functional group, comprising at least one x-fold (x≧1) chemoselectively incorporated phosphoramidate group of general formula (I)

—NHPO(OR1)(OR1′) (I)
and/or at least one x-fold (x≧1) chemoselectively incorporated phosphonamide group of general formula (1a)
—NHPO(R1)(OR1′) (Ia)
wherein R1 and R1′ is selected from the group containing glycerol, polyglycerol, PEG polymers of the general empirical formula C2nH4n+2On+1 with n≧1, methyl, ethyl, or butyl;
functionalized Cn-alkyl chains with n≧1, aryls, heteroaryl, silyl, fluorophores, saccharides, peptides, crown ethers, or a linker, which links the aforementioned groups, and wherein R1 and R1′ can be identical to or different from one another,
wherein the further functional group in the macromolecule is unprotected.

3 more elements

Dependencies are inferred from the claim text.

Compound modified by a phosphoramidate and/or phosphonamide group and use thereof

Life of this patent

Compound modified by a phosphoramidate and/or phosphonamide group and use thereof

Life of this patent

Abstract

Claims12