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US 8,575,276 B2Granted
Biomimetic compounds and synthetic methods therefor
AssigneeKnc Ner Acquisition Sub, Inc.
InventorBruce P. Lee
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Abstract
Synthesis methods for creating polymeric compounds comprising dihydroxyphenyl derivatives (DHPD), or DHPp i.e. polymers modified with DHPD, with desired surface active effects are described. The polymer backbone of DHPp has structural or performance features that can be tailored to control physical properties of DHPp, allowing it to be useful for different applications i.e. tissue adhesives or sealants, adhesion promoting coatings, and antifouling coatings.
Claims20
A method for adhering a first surface to a second surface in a subject, comprising:
- a) providing a subject;
- b) providing a DHPD-modified linear polymer (DHPp) according to Formula (I):
- wherein LG is an optional linking group, DHPD is a dihydroxyphenyl derivative selected from dopamine or 3,4-dihydroxyhydrocinnamic acid, and pB is a linear polymeric back bone;
- c) applying an effective amount of said phenyl derivative polymer to at least one of said first and said second surface in said subject;
- and
- d) approximating said first surface and said second surface such that said phenyl derivative polymer adheres said first surface to said second surface in said subject.
3 more elements
A method for sealing a surface in a subject, comprising:
- a) providing a subject;
- b) providing a DHPD-modified linear polymer DHPp according to Formula (II):
- wherein R1 is a monomer or prepolymer linked or polymerized to form a linear polymeric backbone (pB), DHPD is a dihydroxyphenyl derivative selected from dopamine or 3,4-dihydroxyhydrocinnamic acid, and LG is an optional linking group;
- and
- c) applying an effective amount of said phenyl derivative polymer to said surface in said subject.
2 more elements
Dependencies are inferred from the claim text.