Multi-solution bone cements and methods of making the same
AssigneeSyracuse University
InventorsJulie M. Hasenwinkel, Imad K. Merkhan, Jeremy L. Gilbert
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Abstract
The present invention relates to bone cements and, more particularly, to multi-solution bone cements and methods for making the same. An embodiment of the present invention provides multi-solution bone cements which include cross-linked PMMA beads, thereby providing for a significant increase in the polymer-to-monomer (P:M) ratio. Another embodiment of the present invention provides cross-linked PMMA beads which are surface modified with unsaturated carbon double bonds. A further embodiment of the present invention provides multi-solution bone cements made with PMMA-PMMA spherical brush polymers.
Claims9
A multi-solution bone cement comprising:
- a first solution comprising a mixture of an initiator, a linear polymer, cross-linked beads, wherein said cross-linked beads comprise cross-linked poly(methyl methacrylate) (PMMA) beads, wherein a surface of each of said cross-linked beads comprise functional reactive sites, and wherein said functional reactive sites comprise carbon-carbon double bonds, and a monomer;
- a second solution comprising a mixture of an activator, said linear polymer, said cross-linked beads, and said monomer;
- and
- wherein said cross-linked PMMA beads comprising said functional reactive sites comprise the following formula:
A method of forming a multi-solution bone cement system,
- comprising the steps of:
- synthesizing cross-linked beads;
- mixing said cross-linked beads with a linear polymer to form a first mixture;
- mixing a monomer with a first initiator to form a second mixture;
- mixing said first mixture and said second mixture in a first container to form a first solution;
- mixing said cross-linked beads with said linear polymer to form a third mixture;
- mixing said monomer with an activator to form a fourth mixture;
- mixing said third mixture and said fourth mixture in a second container to form a second solution;
- sealing said containers and mixing said solutions within said containers;
- and
- storing said containers;
- wherein said cross-linked beads comprise cross-linked poly(methyl methacrylate) (PMMA) beads, wherein a surface of each of said cross-linked beads comprise functional reactive sites, wherein said functional reactive sites comprise carbon-carbon double and wherein said cross-linked PMMA beads comprising said functional reactive sites comprise the following formula:
Dependencies are inferred from the claim text.