Use of nitrooxyderivatives of drug for the treatment of muscular dystrophies

A method of treating muscular dystrophies consisting of administering to a subject a nitric oxide releasing compound of formula (Ia)

• M-X—Y—ONO2 (Ia)
• or enantiomers or diastereoisomers thereof, wherein in the general formula (Ia), M, X and Y have the following meanings:
• M is a residue selected from the group consisting of:
• X is —O—, —S— or —NR1—, wherein R1 is H or linear or branched
• C1-C6 alkyl;
• Y is a bivalent radical having the following meanings:
• a)—straight or branched C1-C20 alkylene being
• optionally substituted with one or more of the substituents selected from the group consisting of:
• halogen atoms, hydroxy, —ONO2 and T, wherein T is —OC(O)(C1-C10 alkyl)-ONO2 or —O(C1-C10 alkyl) ONO2;
• C5-C7 cycloalkylene group optionally substituted with linear or branched C1-C10 alkyl group;
• wherein n is an integer from 0 to 20;
• n1 is an integer from 1 to 20 wherein when Y is selected from the bivalent radicals mentioned under b) and c) then the —ONO2 group of formula is bound to —(CH2)n1—;
• wherein
• X1=—OCO— or —COO— and R2 is H or CH3;
• na is an integer from 1 to 20;
• n2 is an integer from 0 to 2;
• wherein:
• Y1 is —CH2—CH2—(CH2)n2—;
• or —CH═CH—(CH2)n2—;
• X1, na, n2 and R2 are as defined above;
• wherein:
• na and R2 are as defined above, R3 is H or —COCH3;
• wherein when Y is selected from the bivalent radicals mentioned under d)-f) then the —ONO2 group of formula (I) is bound to —(CH2)na;
• wherein when X is —NR1, wherein R1 is as above defined Y cannot be f);
• and
• wherein
• X2 is —O— or —S—;
• n3 is an integer from 1 to 6 and
• R2 is as defined above.