Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
AssigneeGenmedica Therapeutics Sl
InventorsAlec Mian, Luc Marti Clauzel, Eric Mayoux, Silvia Garcia-Vicente, Marta Serrano Munoz, Antonio Zorzano Olarte, Julio Cesar Castro Palomino Laria
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Abstract
The present invention is directed to methods for treating metabolic disorders with compounds that are conjugates. The conjugates of the present invention are comprised of salicylic acid, triflusal, diflusinal, salsalate, IMD-0354, ibuprofen, diclofenac, licofelone, or HTB, and one or more antioxidants.
Claims12
A method for treating a metabolic disorder selected from type I diabetes, type II diabetes, Latent Autoimmune Diabetes of Adulthood (LADA), hyperglycemia, elevated free fatty acids, elevated triglycerides and insulin resistance in a mammal or patient comprising administering to the mammal or patient in need of such treatment a therapeutically effective amount of (R)-2-acetamido-3-(2′,4′-difluoro-4-hydroxybiphenylcarbonylthio)propanoic acid or a pharmaceutically acceptable salt thereof.
A method of treating Latent Autoimmune Diabetes of Adulthood (LADA), in a mammal or patient comprising administering to the mammal or patient in need of such treatment a therapeutically effective amount of a pharmaceutical composition comprising (R)-2-acetamido-3-(2′,4′-difluoro-4-hydroxybiphenylcarbonylthio)propanoic acid or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.