US 8,575,210 B2 · Use of indole derivatives as NURR-1 activators for treating parkinson's disease

Abstract

The present invention relates to a compound derived from indole, especially a therapeutically useful compound, characterized in that it is selected from compounds of formula (I) in which R1 represents a halogen or a trifluoromethyl group, R2 represents a hydrogen atom or a C1-C4 alkyl group, R3 represents an isopropyl (1-methylethyl) group or a tert-butyl (1,1-dimethylethyl) group and n=3 or 4 and pharmaceutically acceptable salts of said compounds of formula (I). Application: Treatment of neurodegenerative diseases and more particularly of Parkinson's disease.

Claims9

Dependent claims

A compound selected from the group consisting of

i) compounds of formula (I)
in which
R1 represents a trifluoromethyl group,
R2 represents a hydrogen atom or a C1-C4 alkyl group,
R3 represents an isopropyl group or a tert-butyl group and
n=3 or 4
and
ii) pharmaceutically acceptable salts of said compounds of formula (I).

5 more elements

Dependencies are inferred from the claim text.

Facts

Application

13/003,554Filed 9 Jul 2009

Priority

FR 08 5471210 Jul 2008

Published

US 2011/0178150 A121 Jul 2011

Granted

5 Nov 2013

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

C07D 209/18
With substituted hydrocarbon radicals attached to carbon atoms of the hetero ring: radicals substituted by carbon atoms having three bonds to…
A61K 9/1635
Organic macromolecular compounds: obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, polyacrylates
A61K 9/1652
Organic macromolecular compounds: polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
A61P 25/00
Drugs for disorders of the nervous system

Use of indole derivatives as NURR-1 activators for treating parkinson's disease

Life of this patent

Use of indole derivatives as NURR-1 activators for treating parkinson's disease

Life of this patent

Abstract

Claims9