Chemical compounds

A compound of formula (1)

• wherein
• Qa is a ring system optionally substituted by one or more identical or different Ra and/or Rb, selected from among C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• R1 and R2 are selected independently of one another from among hydrogen, halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4haloalkyl, —NH2, —CN, —NHC1-4alkyl, —N(C1-4alkyl)2, —OH, —OC1-4alkyl, HO—C1-4alkylene-, C1-4alkyl-O—C1-4alkylene-, H2N—C1-4alkylene-, —OC1-4haloalkyl, (C1-4alkyl)NH—C1-4alkylene- and (C1-4alkyl)2N—C1-4alkylene, while alkyl, alkenyl, alkynyl and alkylene mentioned in the above groups may optionally be substituted by one or more identical or different halogens;
• the ring system Qb is
• each R3 is independently selected from among halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4haloalkyl, —NH2, —CN, —NHC1-4alkyl, —N(C1-4alkyl)2, —OH, —OC1-4alkyl, HO—C1-4alkylene-, HO—C2-4alkylene-O—, C1-4alkyl-O—C1-4alkylene-, C1-4haloalkyl-O—C1-4alkylene-, H2N—C1-4alkylene-, C1-4alkyl-O—C2-4alkylene-O—, (C1-4alkyl)NH—C1-4alkylene-, (C1-4alkyl)2N—C1-4alkylene-, —OC1-4haloalkyl, H2N—C2-4alkylene-O—, —NH(C2-4alkylene-NH2), —NH[C2-4alkylene -NH(C1-4alkyl)], —NH[C2-4alkylene-N(C1-4alkyl)2], (C1-4alkyl)2N—C2-4alkylene-O—, (C1-4haloalkyl)2N—C2-4alkylene-O—, (C1-4haloalkyl)NH—C2-4alkylene-O— and (C1-4alkyl)NH—C2-4alkylene-O—;
• n denotes the number 0, 1, 2 or 3 if Qb corresponds to the ring system Qb-4;
• each n independently denotes the number 0, 1 or 2 if Qb corresponds to one of the ring systems Qb-1, Qb-2, Qb-3 or Qb-5;
• while a group R3 in the ring systems Qb-1 to Qb-5 in each case replaces a hydrogen;
• R4 denotes hydrogen or C1-4alkyl;
• L denotes the group
• R5 and R6 are each independently of one another selected from among hydrogen, halogen, C1-4alkyl, C1-4haloalkyl;
• the ring system QH is selected from among
• R7 and R9 are each independently of one another selected from among hydrogen, halogen, —NRaRa, —N(ORa)Ra, —ORa, —COORa, —CORa, —CONRaRa, —SRa, —NO2 and —CN or denote a group optionally substituted by one or more identical or different Rb and/or Rc, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• R8 is independently selected from among hydrogen, —NRaRa, —N(ORa)Ra, —ORa, —COORa, —CORa, —CONRaRa and —SRa or denotes optionally substituted by one or more identical or different Rb and/or Rc, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• R10 is independently selected from among —NRaRa, —N(ORa)Ra, —ORa and —SRa or a group optionally substituted by one or more identical or different Rb and/or Rc, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• each R11 and R12 is independently selected from among Ra and Rb;
• m denotes the number 0, 1 or 2;
• each Ra independently denotes hydrogen or a group optionally substituted by one or more identical or different Rb and/or Rc, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• each Rb is independently selected from among —ORc, —NRcRc, halogen, —CN, —NO2, —C(O)Rc, —C(O)ORc, —C(O)NRcRc, —S(O)2Rc, —S(O)2NRcRc, —NHC(O)Rc and —N(C1-4alkyl)C(O)Rc as well as the bivalent substituent ═O, while the latter may only be a substituent in non-aromatic ring systems;
• each Rc independently denotes hydrogen or a group optionally substituted by one or more identical or different Rd and/or Re, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• each Rd is independently selected from among —ORe, —NReRe, halogen, —CN, —NO2, —C(O)Re, —C(O)ORe, —C(O)NReRe, —S(O)2Re, —S(O)2NReRe, —NHC(O)Re and —N(C1-4alkyl)C(O)Re, as well as the bivalent substituent ═O, while the latter may only be a substituent in non-aromatic ring systems;
• each Re independently denotes hydrogen or a group optionally substituted by one or more identical or different Rf and/or Rg, selected from among C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• each Rf is independently selected from among —ORg, —NRgRg, halogen, —CN, —NO2, —C(O)Rg, —C(O)ORg, —C(O)NRgRg, —S(O)2Rg, —S(O)2NRgRg, —NHC(O)Rg and —N(C1-4alkyl)C(O)Rg, as well as the bivalent substituent ═O, while the latter may only be a substituent in non-aromatic ring systems and
• each Rg is independently selected from among hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 5-12 membered heteroaryl and 3-14 membered heterocyclyl;
• or a pharmaceutically acceptable salt thereof.