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US 8,575,200 B2Granted
Pyridin-2-yl derivatives as immunomodulating agents
AssigneeActelion Pharmaceuticals Ltd.
InventorsMartin Bolli, Cyrille Lescop, Boris Mathys, Claus Mueller, Oliver Nayler, Beat Steiner
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Abstract
The invention relates to pyridine derivatives of Formula (I) wherein A, R1, R2, R3, R4, R5, R6 and R7 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.
Claims14
A compound of the Formula (I),
- wherein
- A represents
- wherein the asterisks indicate the bond that is linked to the pyridine group of Formula (I);
- R1 represents methyl, ethyl or methoxy;
- R2 represents hydrogen;
- and R3 represents C2-5-alkyl or C1-4-alkoxy;
- or
- R1 represents C2-5-alkyl or C1-4-alkoxy;
- R2 represents hydrogen;
- and R3 represents methyl or ethyl;
- or
- R1 represents methyl, ethyl, or methoxy;
- R2 represents C3-5-alkyl;
- and R3 represents hydrogen;
- R4 represents hydrogen or methoxy;
- R5 represents hydrogen, C1-3-alkyl, or methoxy;
- R6 represents —CH2—(CH2)n—CONR61R62, hydroxy, hydroxy-C2-4-alkoxy, di-(hydroxy-C1-2-alkyl)-C1-2-alkoxy, 2,3-dihydroxy-propoxy, —OCH2—(CH2)n—NR61R62, —OCH2—CH(OH)—CH2—NR6R6, —OCH2—(CH2)n—NHSO2R63, —OCH2—CH(OH)—CH2—NHSO2R63, —OCH2—(CH2)n—NHCOR64, or —OCH2—CH(OH)—CH2—NHCOR64;
- R61 represents hydrogen, methyl, ethyl, 2-hydroxyethyl, carboxymethyl, 1-(C1-5-alkylcarboxy)methyl, 2-carboxyethyl, 2-(C1-5-alkylcarboxy)ethyl, 2-aminoethyl, or 2-methylamino-ethyl;
- R62 represents hydrogen, or methyl;
- R63 represents C1-3-alkyl, methylamino, ethylamino, or dimethylamino;
- R64 represents hydroxymethyl, 2-hydroxyethyl, aminomethyl, methylaminomethyl, 2-aminoethyl, or 2-methylamino-ethyl;
- n represents the integer 1, or 2;
- and
- R7 represents hydrogen, methyl or chloro;
- or a salt thereof.
22 more elements
Dependencies are inferred from the claim text.