Treatment of hepatitis C virus related diseases using hydroxychloroquine or a combination of hydroxychloroquine and an anti-viral agent
AssigneesPanmed Ltd., Genoscience Pharma
InventorPhilippe Halfon
Life of this patent
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Abstract
Methods of treating a hepatitis C virus (HCV) related disease, such as HCV infections in subjects non-responsive to anti-HCV therapy, are described herein, comprising administering to the subject a therapeutically effective amount of hydroxychloroquine. An antiviral agent may be co-administered with the hydroxychloroquine. Methods utilizing synergistic combinations of hydroxychloroquine and an antiviral agent are disclosed. Further disclosed are compositions comprising hydroxychloroquine and an antiviral agent, as well as hydroxychloroquine and uses thereof for the treatment of a hepatitis C virus (HCV) related disease.
Claims12
A method of treating an HCV infection, the method comprising:
- (a) identifying an HCV-infected subject non-responsive to an anti-HCV therapy;
- and
- (b) administering to said HCV-infected subject a therapeutically effective amount of hydroxychloroquine or a pharmaceutically acceptable salt thereof, wherein said therapeutically effective amount of hydroxychloroquine or a pharmaceutically acceptable salt thereof is in a range of from about 500 to about 2000 mg per day, thereby treating the HCV infection.
A method of treating an HCV infection, the method comprising:
- (a) identifying an HCV-infected subject non-responsive to an anti-HCV therapy, wherein said anti-HCV therapy comprises a treatment with PEGylated interferon α-2a or PEGylated interferon α-2b, in combination with ribavirin;
- and
- (b) administering to said HCV-infected subject a therapeutically effective amount of hydroxychloroquine or a pharmaceutically acceptable salt thereof, wherein said therapeutically effective amount of hydroxychloroquine or a pharmaceutically acceptable salt thereof is in a range of from about 500 to about 2000 mg per day, thereby treating the HCV infection.
Dependencies are inferred from the claim text.