Methods for treatment of non-small cell lung cancer
AssigneeArQule, Inc.
InventorsYinpu Chen, Edward G. Garmey, Brian Schwartz
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Abstract
The present invention provides methods of treating non-small cell lung cancer by administering to a subject in need thereof a therapeutically effective amount of a pyrroloquinolinyl-pyrrole-2,5-dione compound in combination with a therapeutically effective amount of an epidermal growth factor tyrosine kinase inhibitor.
Claims19
A method of treating non-small cell lung cancer in a subject in need thereof having a KRAS mutation, the method comprising administering to said subject a therapeutically effective amount of a composition comprising (−)-trans-3-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-4-(1H-indol-3-yl)pyrrolidine-2,5-dione, or a pharmaceutically acceptable salt, prodrug or metabolite thereof, in combination with a therapeutically effective amount of a composition comprising an epidermal growth factor tyrosine kinase inhibitor.
Dependencies are inferred from the claim text.