Tacrolimus preparation for external applications
AssigneeTakata Seiyaku Co., Ltd.
InventorsHironori Masui, Shimpei Sato
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Abstract
The present invention provides tacrolimus containing ointment having low dermal irritation and excellent stability. It was found that an ointment comprising triacetin as a solubilizer for tacrolimus may sufficiently solubilize tacrolimus, has low dermal irritation and excellent stability. Preferably, the ointment of the present invention is an o/o type (oil-in-oil type) ointment in which tacrolimus-solubilized triacetin droplets are dispersed in an ointment base, preferably a mixture of beeswax and petrolatum.
Claims9
An external preparation in an ointment form comprising tacrolimus, triacetin and a base in which tacrolimus-solubilizing triacetin droplets are dispersed in the base.
A method for preparing an external preparation comprising tacrolimus, comprising a step of solubilizing tacrolimus with triacetin.
Dependencies are inferred from the claim text.